Total Bile Acid
Method: Enzymatic recycling Total Bile Acid
Liquid reagent, R1: R2=3:1 Total Bile Acid
Total Bile Acids (TBA) – Clinical Significance
Total bile acids reflect how well the liver, biliary system, and enterohepatic circulation are functioning. They are synthesized in the liver from cholesterol and normally recycled efficiently between the intestine and liver.
Why the test matters
Sensitive marker of liver dysfunction – TBA often rises earlier than ALT, AST, or bilirubin, especially in mild or early liver disease.
Assesses hepatic clearance – Elevated levels suggest impaired uptake, conjugation, or excretion of bile acids by hepatocytes.
Total Bile Acids (TBA) – Sensitivity
Typical sensitivity range
Most modern enzymatic or LC-MS/MS based TBA assays have a sensitivity of around
0.5–1.0 µmol/L
Advanced LC-MS/MS methods can go even lower (≈ 0.1 µmol/L)
Why sensitivity matters
High sensitivity is important for:
- Early liver dysfunction
- Cholestasis
- Intrahepatic cholestasis of pregnancy (ICP)
- Monitoring subtle changes in liver function
Get More Updates
Subscribe Newsletters
Follow Us
Recent News
Contact Us
Address: 121, Hirabaug Society Part II, Near Water Tank, Opp. Alkapuri Society, Ghatlodia, Ahmedabad - 380061
Opening Hour
Mon - Saturday, 10 am - 07 pm
Sunday Closed
2026 © All rights reserved by Digi Triv Technologies